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ea0081ep792 | Pituitary and Neuroendocrinology | ECE2022

The natural course of hypopituitarism at diagnosis and following therapy in non-functioning pituitary macroadenomas

Hussein Ziad , Marcus Hani J , Grieve Joan , Dorward Neil , Bouloux Peirre , Baldeweg Stephanie

Background: Non-functioning pituitary macroadenomas (NFPMs) may present with hypopituitarism. Pituitary surgery and radiotherapy pose an additional risk to pituitary function.Aims: The aim of this study was to assess the incidence of hypopituitarism pre-operatively and the impact of surgery and radiotherapy on pituitary function. Methods: All patients treated with surgery and radiotherapy for NFPMs between 1987 and 2018 with more t...

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ea0038p311 | Pituitary | SFEBES2015

The burden of AIP mutations in pituitary adenoma patients from the UK

Caimari F , Dang M N , Gabrovska P , Hernandez-Ramirez L C , Stals K , Bussell A M , Cranston T , Karavitaki N , Kumar A V , Hunter S , Kearney T , Trainer P J , Izatt I , Bevan J , Quinton R , Grieve J , Baldeweg S E , Grossman A B , Morrison P , Korbonits M

Introduction: Familial isolated pituitary adenoma (FIPA) and young-onset sporadic pituitary adenoma patients are suggested to be screened for mutations in AIP, a gene described in 2006 and amenable to UK testing since 2008.Methods: affected subjects have been tested in Exeter and Oxford genetic laboratories. Data were collected from 120 FIPA-families and 193 sporadic cases with young-onset disease (<30y) from 49 centres in the UK. The Mann&#...

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Endocrine Abstracts

The natural course of hypopituitarism at diagnosis and following therapy in non-functioning pituitary macroadenomas

The burden of AIP mutations in pituitary adenoma patients from the UK

BiosciAbstracts